Vasculitis (vas-kyu-LI-tis) is a state that involves irritation in the blood vessels.The condition occurs if your immune system attack your blood vessels by mistake.This may happen as the result of an infection, a medicine, or another disease or condition.The inflammation can lead to grave problems. Complications depend on which blood vessels, organs, or other body systems are affected.
Vasculitis is a universal term for a group of uncommon diseases that feature inflammation of the blood vessels.The blood vessels of the body are referred to as the vascular system.The blood vessels are comprised of arteries that pass oxygen-rich blood to the tissues of the body and veins that return oxygen-depleted blood from the tissues to the lungs for oxygen.
Vasculitis can affect any of the body's blood vessels.
These include arteries, veins, and capillaries.
Arteries are vessels that carry blood from the spirit to the body's organs, veins are the vessels that carry blood back to the heart, and capillaries are the tiny blood vessels that attach the small arteries and veins.
An inflammation of the blood vessels is acknowledged as vasculitis/ angiitis/ arteritis.It is an auto-immune disease and happens when the body's impervious system instead of affording protection to the body from pathogens starts aggressive the blood vessel. The exact cause is still unclear.
All the blood vessels as well as the arteries, veins and capillaries are affected. Arteries are blood vessels that transport blood from the heart to the body whereas Veins carry blood from the body back to the heart.
Causes of Vasculitis
The causes of most vasculitides are at present unknown. It is clear, however, that the immune system plays a critical role in the tissue damage caused by vasculitis.
The immune system, normally a defensive organ of the body, becomes “hyperactive” in vasculitis because of some unknown incentive, leading to inflammation within the body's tissues. Inflammation in blood vessel walls leads to contraction of the vessels.
Vasculitis occurs when your body attacks your blood vessels. It's not always clear why this happens, but an infection, some cancers, certain immune system disorders or an allergic answer may serve as the trigger.
Symptoms of Vasculitis
General symptoms of vasculitis include fever, body ache, arthritis pain, weight loss and fatigue.
The patient develops purpura, which is a hard, purple blotch on the skin. Blackened areas of gangrene come into view in the areas of skin where there is no blood flow.
2. Loss of appetite
3. Weight loss
4. Fatigue (tiredness)
5. General aches and pains
Treatment of Vasculitis
Treatment of vasculitis is usually the same, no matter what organ or tissue is involved. The goal is to decrease the immune system's manufacture of antibodies, usually with medications called steroids.
Steroids, such as prednisone, stop swelling. Severe cases may be treated with a drug called cyclophosphamide, which kill immune system cells.
Purpose of review: To review the current text of childhood primary and secondary central nervous system (CNS) vasculitis and to assess the rising degree of difference diagnosis of inflammatory and no inflammatory brain diseases.