Joseph Letzelter’s Systemic Lupus Erythematosus General Features
Systemic lupus erythematosus (SLE) is a chronic and dangerous disease with many symptoms. SLE is an autoimmune disease in which the body’s own immune structure is directed against the body’s own tissues. The origin of SLE is not known. This disease is common to all ages, but is more common in young women. The fabrication of autoantibodies direct to immune complex formation. The immune complex deposition in many tissues direct to the manifestations of the disease. Immune complexes can be deposited in glomeruli, lungs, skin, mesothelium, synovium, and other places. Many SLE affected patients develop renal complications.
Generally normal healthy immune systems develop an antibodies that will help to fight and kill the bacteria as well as viruses that affect the body. In systemic lupus erythematosus, the body’s immune system malfunctions by attacking by itself. Rather than shielding the body from destructive foreign substances, the immune system produces autoantibodies plus sensitized cytotoxic T cells that injure the host’s own tissues. The immune system mistakes host tissues for foreign ones plus increase an inappropriate attack. These autoantibodies contribute to a multitude of destructive effects in the body.
Relative toward the immune system, the initial obvious abnormality of SLE is the hyperactivity of B lymphocytes. Nor intrinsic B lymphocyte abnormalities (a subject of current research) or else defects in assistant T lymphocytes (CD4 cells-that regulate B lymphocyte function) are probable contributors to the extreme activation of B lymphocytes. The hyperactivity of B lymphocytes consequences in the production of abnormal antibodies, the hallmark symptom of systemic lupus erythematosus. In SLE, abnormal B lymphocytes instinctively secrete improved amounts of abnormal antibodies that contribute negatively to a lacking immune system. The production of irregular autoantibodies could also react through a whole host of subcellular antigens. Autoantibodies cause harm by altering the job of target organs as well as tissues. They might also contribute to multi-systemic swelling.