Systemic Lupus Erythematosus (SLE or lupus) is a chronic autoimmune disease that can be fatal, though with recent medical advances, fatalities are becoming increasingly rare. It may affect the skin, joints, kidneys, and other organs. Systemic lupus erythematosus involves chronic inflammation that can affect many parts of the body. SLE (lupus) is an autoimmune disease. This means there is a problem with the body’s normal immune system response. Normally, the immune system helps protect the body from harmful substances. Fever occurs in 90% of patients with SLE and is usually caused by the inflammatory process of the disease, not by infection. It is low-grade except during an acute lupus crisis. SLE may be mild or severe enough to cause death.

SLE often begins with a skin rash over the nose and cheeks that is shaped like a butterfly and made worse by exposure to the sun. This may be accompanied by tiredness and joint pains. SLE symptoms may develop slowly over months or years, or they may appear suddenly. Symptoms tend to be worse during winter months, perhaps because prolonged exposure to sunlight in the summer causes a gradual build-up of factors that trigger symptoms months later. SLE is one of several diseases known as the great imitator because its symptoms vary so widely it often mimics or is mistaken for other illnesses. There are an estimated 50,000 people with SLE in the UK. Women are nine times more likely to be affected than men. SLE commonly starts in the teens and 20s.

About 90% of people who have lupus are young women in their late teens to 30s. Older men and women can also be affected. SLE or lupus occurs in all parts of the world but may be more common in blacks and in Asians. Treatment depends on which organs are affected and whether the lupus is mild or severe. Immunosuppressants may be used to relieve symptoms and control the disease, while physiotherapy can help to relieve joint problems. Sun exposure should be avoided and infections treated promptly. Bone marrow transplant autologous stem cell transplants are under investigation as a possible cure. Nonsteroidal anti-inflammatory drugs for fever, arthritis, and headache. Antimalarial drugs for pleurisy, mild kidney involvement, and inflammation of the tissue surrounding the heart

Lupus Erythematosus Treatment and Prevention Tips

1. Nonsteroidal anti-inflammatory medications (NSAIDs) are used.

2. Corticosteroid creams are used to treat skin rashes.

3. Sun exposure should be avoided and infections treated promptly.

4. Immunosuppressants may be used to relieve symptoms and control the disease.

5. Hydroxychloroquine (Plaquenil) is an antimalarial medication found to be particularly effective for SLE patients.


8 thoughts on “Systemic Lupus Erythematosus Rash Causes

  1. Mandy Cakes

    This is a lot to ask, I know. But if someone could review my APA paper I would GREATLY appreciate it. ?
    I think my greatest problem is with grammer errors and my in-text citations. Also, all of those citations that repeat themselves look funny to me. They can’t be right? Can they? I’m also confused with secondary citations. I think they’re a no no but I can’t get a clear answer on what they are. Here’s the paper. Please kindly review if you’d like. I’d love yah for it.

    Kisses
    Mandi

    (Title page not included)

    Introduction
    Lupus is an autoimmune disease that permits the affected body to build antibodies to attack its own cells as if they were foreign. There are three main types of lupus. They are discoid, drug induced, and Systemic lupus erythematosus (Encyclopedia Britannica, 2009). Doctors must be careful in diagnosing lupus since it can easily be confused with other diseases (Rahman & Isenberg, 2008). Lupus is capable of attacking any part of the body but for the most part it mainly affects the skin, kidneys, joints, heart, gastrointestinal tract, and serous membranes (Encyclopedia Britannica, 2009). The cause of Lupus is currently unknown. Lupus truly is a sickness of mystery since the cause and cure have currently been unidentified. However, there are known genetic (Encyclopedia Britannica, 2009) and environmental (Rahman & Isenberg, 2008) aspects that have been known to trigger this illness. On an inspiring note, there is presently a study being conducted with mice in search for the cure of lupus.

    Discussion
    Lupus is an autoimmune disease that is known to be a chronic (continuous or reoccurring) inflammatory illness that has the ability to attack any region of the body (Encyclopedia Britannica, 2009). The symptoms of the disease are painful or swollen joints and muscle pain, unexplained fever, red rashes, chest pain when breathing deeply, loss of hair, pale or purple fingers or toes from cold or stress (also known as Raynaud’s phenomenon), sensitivity to the sun swelling in legs or around eyes, mouth ulcers, swollen glands and extreme fatigue (WebMD, 2008). Those that suffer from lupus may never have the same symptoms as another person with the disease (Encyclopedia Britannica, 2009). However, the most common areas of the body affected are the skin, kidneys, joints, heart, gastrointestinal tract, and serous membranes (Encyclopedia Britannica, 2009).. Also in most cases in order for a doctor to diagnose lupus the patient must illustrate at least four (Encyclopedia Britannica, 2009) of the listed symptoms.
    The actual cause of the disease is unknown. However, there are genetic and environmental characteristics that could trigger lupus to develop. Many patients that suffer from lupus have a genetic association with the disease (Encyclopedia Britannica, 2009). Lupus could be the result of mutated genes of interferon and the genes that play vital roles in regulating the immune response (Encyclopedia Britannica, 2009). If a patient has a genetic link to lupus there are also environmental aspects that could trigger lupus. They are infection, ultraviolet light, certain drugs like; procainamide, hydralazine, and quinidine (Rahman & Isenberg, 2008), and extreme stress (Encyclopedia Britannica, 2009). Factors that potentially contribute to the progression of lupus are interleukins and interferons (immune molecules). Interleukins and interferons have been shown to control the autoantibody release in response to certain bodily stimuli (Encyclopedia Britannica, 2009).
    Lupus commonly affects women, African Americans, and Asians more than any other group (Rahman & Isenberg, 2008). Since 90% of all patients with lupus are female, women between the ages of 15-50 should be tested for lupus if they portray at least one of the symptoms (Rahman & Isenberg, 2008). Also, there is an increased risk of lupus in people who already have the Epstein-Barr virus. (Rahman & Isenberg, 2008)
    The healthy immune system’s mission is to protect the body from infections and foreign objects within the body. When the immune system is working properly it will recognize the foreign bacteria, virus, or objects as non-self. Upon recognition that something does not belong, it will build antibodies against the unwanted agent, attack and destroy it (Marieb, 2009, p. 408 & 410). However, the activities of the immune system are much different when the body is affected with lupus. Instead of the body producing antibodies against foreign bacterial that do not belong, the immune system will produce an autoantibody that attacks the body’s own cells and tissues. The reason for this is because they can not recognize their own cells or tissue as self. When an autoantibody attack occurs, the autoantibodies will attach themselves to various tissues and cells (Rahman & Isenberg, 2008). When this happens the body’s inflammatory response occurs. The same thing happens when we have been hurt and the tissue has truly been damaged.
    There are a few different ways Lupus can affect the body, for example in nearly all individuals that suffer from lup

    1. mgunnycappo

      It’s a pretty good paper but in the beginning you made an error. There are four types of Lupus. Neo Natal (babies), Drug Induced, Discoid and Systemic. Then after that you should state that your paper is talking about Systemic Lupus because they symptoms you go on to describe are those of Systemic Lupus. Your citings follow the APA guidelines. I couldn’t see the entire paper as it got cut off. Also couldn’t see your works cited page. You don’t show any quotation marks so I’m assuming that you didn’t plagerize any of the information directly from the material.

  2. Mandy Cakes

    This is a lot to ask, I know. But if someone could review my APA paper I would GREATLY appreciate it. ?
    I think my greatest problem is with grammer errors and my in-text citations. Also, all of those citations that repeat themselves look funny to me. They can’t be right? Can they? I’m also confused with secondary citations. I think they’re a no no but I can’t get a clear answer on what they are. Here’s the paper. Please kindly review if you’d like. I’d love yah for it.

    Kisses
    Mandi

    (Title page & reference page not included)

    Introduction
    Lupus is an autoimmune disease that permits the affected body to build antibodies to attack its own cells as if they were foreign. There are three main types of lupus. They are discoid, drug induced, and Systemic lupus erythematosus (Encyclopedia Britannica, 2009). Doctors must be careful in diagnosing lupus since it can easily be confused with other diseases (Rahman & Isenberg, 2008). Lupus is capable of attacking any part of the body but for the most part it mainly affects the skin, kidneys, joints, heart, gastrointestinal tract, and serous membranes (Encyclopedia Britannica, 2009). The cause of Lupus is currently unknown. Lupus truly is a sickness of mystery since the cause and cure have currently been unidentified. However, there are known genetic (Encyclopedia Britannica, 2009) and environmental (Rahman & Isenberg, 2008) aspects that have been known to trigger this illness. On an inspiring note, there is presently a study being conducted with mice in search for the cure of lupus.

    Discussion
    Lupus is an autoimmune disease that is known to be a chronic (continuous or reoccurring) inflammatory illness that has the ability to attack any region of the body (Encyclopedia Britannica, 2009). The symptoms of the disease are painful or swollen joints and muscle pain, unexplained fever, red rashes, chest pain when breathing deeply, loss of hair, pale or purple fingers or toes from cold or stress (also known as Raynaud’s phenomenon), sensitivity to the sun swelling in legs or around eyes, mouth ulcers, swollen glands and extreme fatigue (WebMD, 2008). Those that suffer from lupus may never have the same symptoms as another person with the disease (Encyclopedia Britannica, 2009). However, the most common areas of the body affected are the skin, kidneys, joints, heart, gastrointestinal tract, and serous membranes (Encyclopedia Britannica, 2009).. Also in most cases in order for a doctor to diagnose lupus the patient must illustrate at least four (Encyclopedia Britannica, 2009) of the listed symptoms.
    The actual cause of the disease is unknown. However, there are genetic and environmental characteristics that could trigger lupus to develop. Many patients that suffer from lupus have a genetic association with the disease (Encyclopedia Britannica, 2009). Lupus could be the result of mutated genes of interferon and the genes that play vital roles in regulating the immune response (Encyclopedia Britannica, 2009). If a patient has a genetic link to lupus there are also environmental aspects that could trigger lupus. They are infection, ultraviolet light, certain drugs like; procainamide, hydralazine, and quinidine (Rahman & Isenberg, 2008), and extreme stress (Encyclopedia Britannica, 2009). Factors that potentially contribute to the progression of lupus are interleukins and interferons (immune molecules). Interleukins and interferons have been shown to control the autoantibody release in response to certain bodily stimuli (Encyclopedia Britannica, 2009).
    Lupus commonly affects women, African Americans, and Asians more than any other group (Rahman & Isenberg, 2008). Since 90% of all patients with lupus are female, women between the ages of 15-50 should be tested for lupus if they portray at least one of the symptoms (Rahman & Isenberg, 2008). Also, there is an increased risk of lupus in people who already have the Epstein-Barr virus. (Rahman & Isenberg, 2008)
    The healthy immune system’s mission is to protect the body from infections and foreign objects within the body. When the immune system is working properly it will recognize the foreign bacteria, virus, or objects as non-self. Upon recognition that something does not belong, it will build antibodies against the unwanted agent, attack and destroy it (Marieb, 2009, p. 408 & 410). However, the activities of the immune system are much different when the body is affected with lupus. Instead of the body producing antibodies against foreign bacterial that do not belong, the immune system will produce an autoantibody that attacks the body’s own cells and tissues. The reason for this is because they can not recognize their own cells or tissue as self. When an autoantibody attack occurs, the autoantibodies will attach themselves to various tissues and cells (Rahman & Isenberg, 2008). When this happens the body’s inflammatory response occurs. The same thing happens when we have been hurt and the tissue has truly been damaged.
    There are a few different ways Lupus can affect the body, for example in nearly all individuals tha

    1. slawekp2001

      Get rid of all the citations that are repeating themselves,that a big no no.Use each citation only once ok.I think alround its great and you should get a good grade.Hope it helps

  3. skylar

    Have you done your H1N1 (Swine Flu) shot research? Read this…..?
    My bf did research on a article….kinda long but important, just do a quick read and you see the important parts!!!

    Excerpts from TORONTO STAR article:
    Pregnant women will get a shot of Aussie H1N1 vaccine
    October 27, 2009

    OTTAWA–Pregnant women will be able to get an alternative version of the H1N1 vaccine by early next week.The Australian imports do not contain adjuvant – a substance added to the vaccine to stretch supply and boost immunity. (YOU HAVE TO ASK YOURSELF, WHY CAN’T ALL OF OUR VACCINES BE OF THIS KIND?)

    The adjuvant used in most of the 50.4 million doses being produced by GlaxoSmithKline Inc. at its plant in Ste. Foy, Que., is a mixture of squalene (derived from fish oil), tocopherol (containing vitamin E) and an emulsifier called polysorbate. (SO WHAT ARE THEY NOT TELLING US? WELL LETS DO OUR OWN LITTLE RESEARCH. LET’S LOOK BELOW

    Sweden’s Karolinska Institute found that on injection, an “otherwise benign molecule like squalene can stimulate a self-destructive immune response,” even though it occurs naturally in the body.

    Other research shows that squalene is the experimental anthrax vaccine ingredient that caused devastating autoimmune diseases and deaths for many Gulf War veterans from the US, UK, and Australia, yet it continues in use today and for new vaccines development in labs.

    Other autoimmune diseases are also linked to humans injected with squalene. “… squalene-based adjuvants can induce autoimmune diseases in animals…observed in mice, rats, guinea pigs and rabbits.
    -Micropaleontologist Dr. Viera Scheibner conducted research into the adverse effects of adjuvants in vaccines and wrote:

    Squalene “contributed to the cascade of reactions called “Gulf War syndrome. (GIs developed) arthritis, fibromyalgia, lymphadenopathy, rashes, photosensitive rashes, malar rashes, chronic fatigue, chronic headaches, abnormal body hair loss, non-healing skin lesions, aphthous ulcers, dizziness, weakness, memory loss, seizures, mood changes, neuropsychiatric problems, anti-thyroid effects, anaemia, elevated ESR (erythrocyte sedimentation rate), systemic lupus erythematosus, multiple sclerosis, ALS, Raynaud’s phenomenon, Sjorgren’s syndrome, chronic diarrhea, night sweats and low-grade fever.”

    The Washington Post also confirmed that the H1N1 flu vaccine l contains the mercury derivative thiomersal, a toxin linked with autism and neurological disorders.

    The swine flu shot ingredients also include formaldehyde, a known carcinogen, and Polysorbate 80, a preservative which causes infertility in mice.

    -polysorbate
    It is toxic and should not be eaten, drunk, put on the skin or injected.

    Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions.”

    Put in plain English, polysorbate 80 can affect your immune system and cause severe anaphylactic shock which can kill.

    THIS IS ONLY THE TIP OF THE ICEBERG OF REAL PROFFESIONAL RESEARCH
    ALL YOU HAVE TO DO IS A LITTLE RESEARCH YOURSELF AND YOU’LL GET THE TRUTH
    so do you really want to drink the kool-aid now?

    SO my question is…how many people are planning to get this shot without knowing what is in it? What are your thoughts on the shot?

    Thanks everyone!
    Anything AFTER the LOOK BELOW is outside research not from the article, the article tells you that it is safe, yet research can show otherwise.

    1. BJC

      You have been mislead by the anti-vaccine propoganda machine. With their half-truths and inflammatory language they have been deceiving the public for too long. I also think you need to reconsider your use of the phrase “real professional research”.

      Were you aware that vaccines that don’t contain adjuvants have to have far more toxin (antigen) in them than vaccines that have adjuvants? We use adjuvants to be able to provide a vaccine with less toxin and still get the same immune response. Why can’t all our vaccines be like that? There is the answer.

      The studies you mention are being taken completely out of context and many of them cannot be applied to the presence of these substances in vaccines. (I checked up on your sources..ps. The Karolinska Institute thesis where the info was derived from does not say what you say it does…it is being horribly misinterpreted by people without a scientific knowledge base) It’s like providing someone with the toxicity information of formaldehyde in mass quantities (it can cause this and that and do this….ooooh it’s so scary) and talk about that in relation to vaccines that MAY contain microscopic traces of formaldehyde in them, and ignoring the fact that an infant has 10x more formaldehyde coursing through his/her veins produced as a metabolic intermediary than could be found in 10 vaccines. Do you see how this information is easy to misconstrue? Formaldehyde that may be present in some vaccines cannot cause cancer. Why is there formaldehyde traces in vaccines…..they prevent bacterial and viral contamination. Before the inclusion of formaldehyde in the production process (again only trace elements of it are left, if any at all, in the final vaccine product)…..people died from bacterial contamination of vaccines. The only people at risk are those who are allergic to formaldehyde and I have not heard reference in the literature to this allergy being common.

      This is one of the main tactics behind the propganda machine. Twisting things and using studies out of context, or using studies that are not scientifically sound and have not been peer-reviewed. And, the general public is not informed enough to be able to be critical of the information and so are easily mislead by the lies and inflammatory language

      Saying that squalene was responsible, or even “contributed to the cascade” with deaths/illness in Gulf War veterans who received Anthrax vaccinations is patently untrue and completely innacurate. There have been no deaths caused by squalene in vaccinations. A micropaleontologist provided that gem of a quote, I see. Are you aware of what a micropaleontologist is? Hint hint: paleontology is the study of the forms of life existing in prehistoric or geologic times, as represented by the fossils of plants, animals, and other organisms. She sounds super-qualified to be doing research on vaccines!

      Saying that squalene in vaccines has induced autoimmune diseases (they are referring to arthritis which is an AI disease) happened when the mineral oil was applied generously to the exterior of these animals’ mucosal membranes in quantities so much larger than what would be contained in a vaccine…..again with the twisting…..

      Oh, and ANY foreign substance can cause severe anaphylaxis if you are allergic to it…..but in the context of what you were writing it makes it seem like it is common and very scary. Squalene has not, to my knowledge, ever been associated with allergies in large amounts of people (or even a smallish number of people)

      And PLEASE, mentioning the “link” between autism and other neurological disorders……which is again, hogwash. No link has ever been established. And how is information on this being twisted by the anti-vaccine propaganda machine?. Check out the difference between methyl mercury and ethyl mercury…one of which is a possible ingredient in some vaccines and the other (VERY DIFFERENT) chemical is what causes environmental neourological disorders when a person is exposed for a lengthy time. Often when the anti-vaccine propaganda machine uses information about mercury…they forget to tell people the information they are providing is for a completely different chemical. Ethyl mercury (thimerosal) has been shown to clear the body very quickly. Methyl mercury (not used in vaccines, but found in some industrial workplaces) is a chemical that our body’s cannot clear quickly and which result in long term exposure. We know, conclusively, that mercury causes brain damage only through long term exposure. Ethyl vs. methyl…..didn’t see you talk about that in your post. The link does not exist.

      And now to address polysorbate 80. Polysorbate 80 is an emulsifier and solubilizer that is used in MANY foods (including ice cream) and is used in MANY medications that are given using an IV. Ever had IV meds before?

      In conclusion, your data is bogus and at the very least, taken completely out of context. The real professional research you have done has been to visit websites created by the anti-vaccine propaganda machine and taken the bait hook, line, and sinker.

      My problem with your posting has to do with the fact that you are passing on the lies and misinformation that will end up causing more deaths and anguish. That is dangerous, unethical, and egregious. Please stop spreading lies.

  4. Dance-a-Holic

    I need help editing my research paper. I’m really bad at papers…..please help!?
    Well, its on lupus. I have the intro and two body paragraphs, and I still need to do the conclusion. So, I was wondering what I should change on my paper, and what I need to add..? I also have to do a powerpoint based on the paper, that should last a minimum of 5 minutes up to 15.

    The reason why I chose this topic was because my dad has lupus, and I wanted to know more about the topic. He was diagnosed with lupus when he was about fourteen years old. He still receives treatment for it by going in for blood tests and taking medication He has the most common form of lupus, Systemic Lupus Erythematosus (SLE), in which causes the antibodies to react against his own normal tissue. He has arthritis and joint problems, but nothings wrong with his internal organs. To support my dad and other lupus survivors, my family and I all go to the lupus walk in honor of remembering the people who had lupus that died. The things the audience can expect to read in this paper are the different types of lupus, the symptoms, the treatment and cures.
    Lupus is the result of an unbalanced immune system that can be destructive to any organ in the body. It can be categorized into three groups: discoid lupus Erythematosus, systemic lupus Erythematosus, and drug-induced systemic lupus Erythematosus. DLE is always limited to the skin and is identified by a rash that may appear on the face, neck, and scalp. It can evolve into the systemic form, which can affect any organ or system of the body. Systemic lupus Erythematosus is more severe than discoid lupus and can affect almost any organ or organ system of the body. No two people with SLE will have identical symptoms. Drug-induced systemic Lupus Erythematosus occurs after the use of certain prescribed drugs. It is more common in men, because the drugs are given to them more often.
    Lupus is hard to diagnose because it has a wide range of symptoms involving various parts of the body; and symptoms differ from each person. Most people develop painful joints and a rash, but lupus may also cause fatigue, depressions, and kidney problems. The treatment of lupus varies from person to person because each person has different symptoms. Most people with SLE require a regular blood test to check for lupus flares. Medication is the primary medical treatment for lupus. Presently, there are no other methods available to treat lupus because there is nothing else that can have the necessary impact on the immune system. Currently, there is no cure for lupus, but with early diagnosis and proper medical treatment it can significantly help control the disease.

    thanks. it would be much appreciated!!!!

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