As we mentioned in previous article, conventional medicine plays an important role in treating all kinds of disease and most of the time is the first treatment for a couple who for what ever reason cam not conceive after 1 year of unprotected sexual intercourse or can not carry the pregnancy to full term. Immune system plays an important role in protect our body against forming of free radicals and bacteria and virus, but for what ever reasons, sometime the immune system attack sperm in the women reproductive organs or sperm in the testes in men, leading to infertility In this article, we will discuss how anti-nuclear antibody (ANA) affects fertility in conventional perspective.

1. Definition
Antinuclear antibody is defined as specific class of auto antibodies that have the ability to attack structures in the nucleus of cells instead of performing the normal antibody function. It can be detected through blood sample withdrawn from the patient vein.

2. Causes
a) Infection and inflammation
Infection and inflammation caused by bacteria or virus speeding up the body immune system function, but in some cases, bacteria and virus induce the immune system to produce antibodies which directed against the tissues of the body including antinuclear antibody. b) Medication
i) Phenytoin
Pheytoin may increase the risk of production of antinuclear antibody, leading to increasing the risk of malformations and birth defects.
ii) Antibotics
Long term uses of antibody may increase the rick of the production of antinuclear antibody as the medication causes abnormal reaction to the immune system.
iii) Methyldopa
The medication is used to dilate blood vessels for treating high blood pressure, but long term use of this type of medication may decrease the risk of immune disorder in production of antinuclear antibody.
c) Aging
As we age, the levels of antinuclear antibody increases and in some older adults (5% to 40%) may have mildly elevated levels caused by weakening immune function.
d) Diseases
Some diseases such as lupus erythematosus and rheumatoid arthritis may also increase the rick of the production of antinuclear antibody.

3. How antinuclear antibody effects infertility
Under normal conditions, when a woman becomes pregnant, the white blood cells in her uterus produce protective, blocking antibodies. In case of antinuclear antibody, the white blood cells recognize the fetus as a foreign invasion and attack it, leading to miscarriage.

4. Treatment
a) Heparin
Heparin is a member of anticoagulants,it is a purified preparation derived from animal tissue. It helps to increase the blood in transportation of nutrients to the reproductive organs leading to high chance of fertility and lessening the risk of pregnancy loss.
b) Aspirin
Aspirin is an anti-inflammatory and blood thinner agent, it helps to increase the blood circulating to the reproductive organs, thereby reducing the risk of antinuclear antibody attacking the fetus or the women reproductive tissues. It is recommendation to take 80 mg per day, which is equivalent to a baby aspirin. if necessary.

For the best pregnancy self help program review, please visit http://bestfertility.blogspot.com/
For series of Infertility Articles, please visit
http://fertility-infertility.blogspot.com/


3 thoughts on “Positive Lupus Anticoagulant Antibody

  1. ukind

    problem of repetitive abortions?
    Dear Sir/Madam,
    We are suffering from three continous aborations,
    We had first mis-carriage in the month of July 2007 and this was 6-week pregnancy. After getting jerk in auto-ricksaw, We had to
    go for D&C.

    For Second pregnancy we tried from month of Jan 2008 and we both took medicine Blong and Lycobal finally she is
    able to concive in the month of may 2008 and tests done before pregnacy were
    1) TSH,
    2) Torch IGg, Torch IGm,
    3) Hb,
    4) Serum Prolactin,
    out of these Torch IgG was positive,
    and during pregnacy she were on Duphestron, ecospine, folinext and corion injection (weekly), and she was suffering from vaginal discharge (brown color
    liquid) started from early pregnancy, and there was heart beat measured (95/min). One day she had heavy bleeding we had to gone through D&C again
    in month of Aug 2008. And karyotyping of aborted was Normal. Again this was around 6 week pregnancy.

    For third pregancy, we tried from month of Jan 2009 and she is able to conceive at end of Jan 2009,
    Before pregancy, she was taking tablets folic acid and becasole-z. We did follwing tests before third pregancy
    1) Anti phospholipid Antiboby IgG and IgM,
    2) Cardiolipin Antibody panel
    3) DIlute Russell Viper Venon Line , Lupus Anticoagulant by dRVVT
    4) GTT
    5) Anti B2 Glycoprotein 1
    6) Lupus Anticoagulant
    7) Progolac C
    8) Hb (HB, PLV, ESR, TLC, DLC, Plt C)
    All tests were normal.
    and during third preganacy she were on Tab esscuit, Duphastron, HucoG 5000 mg injection(weekly)
    and during preganacy USG report says there is bicornuate/septate location preganacy and we had to gone thorugh D&C again in month
    of march 2009, We did our karyotyping and karyotyping was normal for both of us,

    After third mis-carriage, doctor advised us to do below tests along with laproscopy and histroscopy
    1) TB IGg, IgM,
    2) TB PCR (Normal),
    3) TB PCR (M. Blood)
    4) N.K Cell
    5) TNF alpha
    6) Secrun prolatin estimation ,
    7) Montex
    8) HSG (Normal)
    9) chest X-ray,
    10)whole abdomental USG,
    11) APTT,
    12) CBC,
    13) glucose fasting,
    14) partial thrombolastin ,
    15) VDRL serum,
    16) HBG AG screen,
    17) Urine culture
    out of above tests TNF alpha and TB IgG was positive and doctor advice AKT4, but she took only for two months
    as during laproscopy and histroscopy doctor says there is no infectiob like TB,
    laproscopy and histroscopy done in month of sept 2009.
    In laproscopy and histroscopy doctor said uterus was sub-septate and he removed the septum, and removed shringe of tubes also.

    Please advise, what could be root cause of problem of repetitive abortions,

    MAny Thanks,

    1. zannyvon

      I am truely sorry your having such a hard time with this. I do not have the answer you are looking for but a bit of advice you may want to post this under trying to concieve and change title of question to “problem of repetitive miscarriages” the folks in TTC may be better able to help you out and understand much more than most of us medical test wise and such. also in a place like this the word abortion tends to rile people up and some will not even look at a question assuming you mean that you are intentionally aborting.

      Prayers and baby dust your way 🙂

  2. ukind

    We are suffering from three continous mis-carriage?
    Dear Sir/Madam,
    We are suffering from three continous mis-carriage,
    We had first mis-carriage in the month of July 2007 and this was 6-week pregnancy. After getting jerk in auto-ricksaw, We had to
    go for D&C.

    For Second pregnancy we tried from month of Jan 2008 and we both took medicine Blong and Lycobal finally she is
    able to concive in the month of may 2008 and tests done before pregnacy were
    1) TSH,
    2) Torch IGg, Torch IGm,
    3) Hb,
    4) Serum Prolactin,
    out of these Torch IgG was positive,
    and during pregnacy she were on Duphestron, ecospine, folinext and corion injection (weekly), and she was suffering from vaginal discharge (brown color
    liquid) started from early pregnancy, and there was heart beat measured (95/min). One day she had heavy bleeding we had to gone through D&C again
    in month of Aug 2008. And karyotyping of aborted was Normal. Again this was around 6 week pregnancy.

    For third pregancy, we tried from month of Jan 2009 and she is able to conceive at end of Jan 2009,
    Before pregancy, she was taking tablets folic acid and becasole-z. We did follwing tests before third pregancy
    1) Anti phospholipid Antiboby IgG and IgM,
    2) Cardiolipin Antibody panel
    3) DIlute Russell Viper Venon Line , Lupus Anticoagulant by dRVVT
    4) GTT
    5) Anti B2 Glycoprotein 1
    6) Lupus Anticoagulant
    7) Progolac C
    8) Hb (HB, PLV, ESR, TLC, DLC, Plt C)
    All tests were normal.
    and during third preganacy she were on Tab esscuit, Duphastron, HucoG 5000 mg injection(weekly)
    and during preganacy USG report says there is bicornuate/septate location preganacy and we had to gone thorugh D&C again in month
    of march 2009, We did our karyotyping and karyotyping was normal for both of us,

    After third mis-carriage, doctor advised us to do below tests along with laproscopy and histroscopy
    1) TB IGg, IgM,
    2) TB PCR (Normal),
    3) TB PCR (M. Blood)
    4) N.K Cell
    5) TNF alpha
    6) Secrun prolatin estimation ,
    7) Montex
    8) HSG (Normal)
    9) chest X-ray,
    10)whole abdomental USG,
    11) APTT,
    12) CBC,
    13) glucose fasting,
    14) partial thrombolastin ,
    15) VDRL serum,
    16) HBG AG screen,
    17) Urine culture
    out of above tests TNF alpha and TB IgG was positive and doctor advice AKT4, but she took only for two months
    as during laproscopy and histroscopy doctor says there is no infectiob like TB,
    laproscopy and histroscopy done in month of sept 2009.
    In laproscopy and histroscopy doctor said uterus was sub-septate and he removed the septum, and removed shringe of tubes also.

    Please advise, what could be root cause of problem of repetitive abortions,

    MAny Thanks,

Leave a Reply

Your email address will not be published. Required fields are marked *